Study on the synthesis of methylated reference and their application in the quantity of curcuminoids using single reference liquid chromatography based on relative molar sensitivity was written by Takahashi, Miki;Morimoto, Koji;Nishizaki, Yuzo;Masumoto, Naoko;Sugimoto, Naoki;Sato, Kyoko;Inoue, Koichi. And the article was included in Chemical & Pharmaceutical Bulletin in 2022.Recommanded Product: Bisdemethoxycurcumin The following contents are mentioned in the article:
We report on the recommendation of the simple and versatility of methylated reference (MR) to improve applications in the single reference (SR)-LC based on relative molar sensitivity (RMS). Three curcuminoids (Curs) such as curcumin, demethoxycurcumin and bisdemethoxycurcumin in turmeric products were determined using authentic standards and methylated curcumin. In addition, high-speed countercurrent chromatog. (HSCCC) purification is necessary to sep. Curs for indicating the RMS. For HSCCC separation, a biphasic solvent system was used to obtain these fractions, which were then subjected to 1H quant. NMR to determine their contents in each test solution Using these solutions, the RMS of Curs are calculated from slopes ratios of calibration curves (three ranges from 0-100μmol/L, r2 > 0.998). The averaged RMS of Curs were 8.92 (relative standard deviation (RSD), 1.17%), 8.97 (2.18%), and 9.61 (0.77%), resp. Cur concentrations in turmeric products can be determined using RMS, peak area, and MR content added in these samples. This proposed method, which is based on chem. methylation and the SR-LC assay has been successfully applied for the simple and reliable estimation of Curs in turmeric products. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Recommanded Product: Bisdemethoxycurcumin).
Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Recommanded Product: Bisdemethoxycurcumin
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem