Design, synthesis and in vitro evaluation of novel SARS-CoV-2 3CLpro covalent inhibitors was written by Stille, Julia K.;Tjutrins, Jevgenijs;Wang, Guanyu;Venegas, Felipe A.;Hennecker, Christopher;Rueda, Andres M.;Sharon, Itai;Blaine, Nicole;Miron, Caitlin E.;Pinus, Sharon;Labarre, Anne;Plescia, Jessica;Burai Patrascu, Mihai;Zhang, Xiaocong;Wahba, Alexander S.;Vlaho, Danielle;Huot, Mitchell J.;Schmeing, T. Martin;Mittermaier, Anthony K.;Moitessier, Nicolas. And the article was included in European Journal of Medicinal Chemistry in 2022.Safety of 2-Methoxyethylamine The following contents are mentioned in the article:
Efforts in the design and synthesis of submicromolar covalent inhibitors when the enzymic activity of the viral protease was used as a screening platform were reported. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Safety of 2-Methoxyethylamine).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Safety of 2-Methoxyethylamine
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem