A facile and green synthetic route to boronic acid esters utilizing mechanochemistry was written by Schnuerch, Michael;Holzweber, Markus;Mihovilovic, Marko D.;Stanetty, Peter. And the article was included in Green Chemistry in 2007.Application of 1003858-50-1 The following contents are mentioned in the article:
A facile and environmentally benign method for the formation of boronic acid esters from corresponding boronic acids is reported. Simple grinding of a 1:1 mixture of the boronic acid (alkyl, aryl, or heteroaryl boronic acid) and the diol (pinacol or 2,2-dimethylpropane-1,3-diol) without a solvent gave the boronic acid esters. A subsequent simple work-up step gave the title compounds in excellent yield and purity. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1Application of 1003858-50-1).
2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application of 1003858-50-1
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem