Copper-Catalyzed Substrate-Controlled Carbonylative Synthesis of α-Keto Amides and Amides from Alkyl Halides was written by Zhao, Fengqian;Ai, Han-Jun;Wu, Xiao-Feng. And the article was included in Angewandte Chemie, International Edition in 2022.COA of Formula: C3H9NO The following contents are mentioned in the article:
Controllable production of α-keto amides and amides from the same substrates is an attractive goal in the field of transition-metal-catalyzed (double-)carbonylation. A novel copper-catalyzed highly selective double carbonylation of alkyl bromides was developed. Moderate to good yields of α-keto amides were obtained as the only products. In the case of alkyl iodides, double- and mono-carbonylation can be achieved controllably under different conditions. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3COA of Formula: C3H9NO).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. COA of Formula: C3H9NO
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem