These common heterocyclic compound, 126-38-5, name is 1-Bromo-2,2-dimethoxypropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C5H11BrO2
EXAMPLE 10 (+-)CIS AND (+-)-TRANS-1-[[2-(BROMOMETHYL)-4-(2,4-DICHLOROPHENYL)-2-METHYL-1,3-DIOXOLAN-4-YL]METHYL]-1H-IMIDAZOLE To a well stirred suspension of 2-(2,4-dichlorophenyl)-3-(1H-imidazol-1-yl)-1,2-propanediol (3.4 g), in toluene (500 mL) and n-butanol (4 mL), add successively with p-toluenesulfonic acid monohydrate (2.47 g) and 2,2-dimethoxybromopropane (3.2 g). Heat the mixture gently at reflux for 36 hr. Treat the reaction mixture in a manner described in Example 7 to give a mixture of the title compounds. Chromatograph on silica gel to provide the title compound, cis-isomer (less polar) m.p. 145-147 C., and trans-isomer (more polar) m.p. 128-130 C.
The synthetic route of 1-Bromo-2,2-dimethoxypropane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Schering Corporation; US4788190; (1988); A;,
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