Catalytic Asymmetric Hydrophosphination as a Valuable Tool to Access Dihydrophosphinated Curcumin and Its Derivatives was written by Teo, Ronald Hong Xiang;Lee, Jeannie Xue Ting;Tan, Wei Ren;Shum, Wen Qian;Li, Yongxin;Pullarkat, Sumod A.;Tan, Nguan Soon;Leung, Pak-Hing. And the article was included in Organometallics in 2021.Recommanded Product: Bisdemethoxycurcumin The following contents are mentioned in the article:
Curcumin and its derivatives were successfully functionalized with secondary phosphines via catalytic asym. dihydrophosphination to give enantioenriched products with up to 95% enantiomeric excess (ee). Subsequently, the medicinal activities of dihydrophosphinated-curcumin Au(I) complexes obtained from the in situ complexation of dihydrophosphinated-curcumin with Au(I) were evaluated using the MKN74 and MCF7 cancer cell lines and compared to existing drugs such as curcumin and cisplatin. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Recommanded Product: Bisdemethoxycurcumin).
Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Bisdemethoxycurcumin
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem