In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 18800-30-1 as follows. Formula: C8H8Br2O
To a solution of 1-bromo-4-(2-bromoethoxy)benzene (6, 1 g, 3.57 mmol), and 4-chloro-1H-pyrazole (439 mg, 4.2 mmol),, K2CO3 (985 mg, 7.14 mmol) and KI (29 mg, 0.17 mmol) were added and then heated at 80 C for 16 h. After completion, water (15 ml) was added into reaction mixture and the aqueous layer was extracted with ethyl acetate (2x15ml). The organic layers were combined, dried (Na2SO4) and concentrated in vacuo to give 1-(2-(4-bromophenoxy)ethyl)-4-chloro-1H-pyrazole (7, 1.03 g, 83%) as white solid. 1H-NMR (400 MHz; CDCl3): d 4.26 (t, J = 5.0 Hz , 2H), 4.44 (t, J = 5.1 Hz , 2H), 6.74 (d, J = 8.9 Hz, 2H), 7.36 (d, J = 8.9 Hz, 2H), 7.44 (s, 1H), 7.51 (s, 1H).
According to the analysis of related databases, 18800-30-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; O’Brien, Alistair; Andrews, Stephen P.; Baig, Asma H.; Bortolato, Andrea; Brown, Alastair J.H.; Brown, Giles A.; Brown, Sue H.; Christopher, John A.; Congreve, Miles; Cooke, Robert M.; De Graaf, Chris; Errey, James C.; Fieldhouse, Charlotte; Jazayeri, Ali; Marshall, Fiona H.; Mason, Jonathan S.; Mobarec, Juan Carlos; Okrasa, Krzysztof; Steele, Kelly N.; Southall, Stacey M.; Teobald, Iryna; Watson, Steve P.; Weir, Malcolm; Bioorganic and Medicinal Chemistry Letters; vol. 29; 20; (2019);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem