Synthetic Route of 645-36-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 645-36-3 as follows.
2,2-diethoxyethan-1-amine 8 (3.63 g; 34.15 mmol) was dissolved in dry DCM (100 ml) and cooled to 0 C, then1,4-cyclohexanedione monoethylene acetal 7 (5.0 g; 31.05 mmol) was added dropwise. After10 min NaBH(OAc)3 (7.89 g; 37.26 mmol) was added in one portion and stirred for 2h atroom temp. The reaction mixture was diluted with DCM and saturated aq. NaHCO3 wasadded slowly, and then stirred for additional 15 min at rt. The layers were separated, theDCM layer was washed couple of times with saturated aq. NaHCO3, water, brine solutionand dried over anhydrous Na2SO4. After concentration the crude residue was filtered throughsilica column to afford pure compound 9a 7.2 g (85% yield).
According to the analysis of related databases, 645-36-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Annamalai, Murali; Hristeva, Stanimira; Bielska, Martyna; Ortega, Raquel; Kumar, Kamal; Molecules; vol. 22; 5; (2017);,
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