Related Products of 53087-13-1, A common heterocyclic compound, 53087-13-1, name is 1-(Benzyloxy)-3-bromobenzene, molecular formula is C13H11BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step-2: Synthesis of l-(benzyloxy)-3-(but-l-yn-l-yl)benzene sealed tubc/90 C/12 h To a stirred solution of l-(benzyloxy)-3-bromobenzene (2.5 g, 9.54 mmol) in 30 mL of MeOH:DMA:H20 (1: 1: 1) in a sealed tube, were added copper iodide (0.181 g, 0.95 mmol) and cesium carbonate (4.3 g, 13.3 mmol) at room temperature. This mixture was degassed with three vacuum/N2 cycles, and were added but-l-yn-l-yltrimethylsilane (2.4 g, 19 mmol, Example- 16, Step-2) followed by Pd(PPh3)2Cl2 (0.334 g, 0.479 mmol). The pressure tube was sealed and heated at 90 C for 12 h. Upon completion by TLC, the reaction mixture was diluted with water (250 mL) and extracted with EtOAc (2 x 100 mL). The combined organic extracts were washed with water, brine, dried over anhydrous sodium sulphate and concentrated under reduced pressure. The crude product was purified by column chromatography using 1% EtOAc in n-hexane to afford l-(benzyloxy)-3-(but-l-yn-l- yl)benzene (1.6 g, 72%).
The synthetic route of 53087-13-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; HAO, Ming-Hong; KORPAL, Manav; NYAVANANDI, Vijay Kumar; PUYANG, Xiaoling; SAMAJDAR, Susanta; SMITH, Peter Gerard; WANG, John; ZHENG, Guo Zhu; ZHU, Ping; (161 pag.)WO2016/196342; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem