Hybrid Synthetic and Computational Study of an Optimized, Solvent-Free Approach to Curcuminoids was written by Stepanova, Valeria A.;Guerrero, Andres;Schull, Cullen;Christensen, Joshua;Trudeau, Claire;Cook, Joshua;Wolmutt, Kyle;Blochwitz, Jordan;Ismail, Abdelrahman;West, Joseph K.;Wheaton, Amelia M.;Guzei, Ilia A.;Yao, Bin;Kubatova, Alena. And the article was included in ACS Omega in 2022.Recommanded Product: Bisdemethoxycurcumin The following contents are mentioned in the article:
A green and optimized protocol has been developed for the preparation of sym. 1,7-bis(aryl)-1,6-heptadiene-3,5-diones and asym. 2-aryl-6-arylidenecyclohexanones with modified substrate scope and good functional group tolerance. Syntheses proceed smoothly under solvent-free conditions, providing moderate to excellent product yields with a minimal workup procedure. Control experiments, spectroscopic, and computational studies support a mechanism involving the boron-assisted in situ generation of imine intermediates. Crystal structures of three curcuminoids and isolated mechanistic intermediates are reported. The data provide insight for the further development of solvent-free protocols toward diverse curcumin derivatives in the fields of pharmaceutical and synthetic chemistries. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Recommanded Product: Bisdemethoxycurcumin).
Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: Bisdemethoxycurcumin
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem