Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22236-10-8, name is 4-(Difluoromethoxy)aniline, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 4-(Difluoromethoxy)aniline
To a solution of 4-difluoromethoxyphenylamine (0.99 g, 6.30 mmol) in EtOH (4.5 mL) at 20 C was added under stirring an aqueous HNO3 solution (67%, d=1.4, 0.43 mL, 6.30 mmol) followed by the addition of cyanamide (0.45 g,10.6 mmol). The resulting solution was stirred at reflux for 12 h. Then the mixture was cooled down to rt, concentrated at reduced pressure and diluted with MTBE (15 mL) to induce crystallization of the product. The resulting suspension was stirred at 20 C for 15 min. The formed precipitate was filtered off, washed with a cold mixture of MTBE/EtOH (3:1, 5 mL) followed by MTBE (5 mL), and air-dried to afford the product (0.95 g, 58%) as a white solid;
According to the analysis of related databases, 22236-10-8, the application of this compound in the production field has become more and more popular.
Reference:
Article; Kubas, Holger; Meyer, Udo; Krueger, Bjoern; Hechenberger, Mirko; Vanejevs, Maksims; Zemribo, Ronalds; Kauss, Valerjans; Ambartsumova, Raisa; Pyatkin, Ilya; Polosukhin, Alexey I.; Abel, Ulrich; Bioorganic and Medicinal Chemistry Letters; vol. 23; 16; (2013); p. 4493 – 4500;,
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