Interaction of bisdemethoxycurcumin with cationic (cetyltrimethylammonium) + nonionic (Tween 20/Tween 60) mixed surfactants: Thermodynamic study and functional improvement was written by Wang, Lu;Liu, YingLin;Weng, Tianxin;Li, Xinyu;Wu, Yushu;Zhao, Yanna;Liu, Jie;Liu, Min. And the article was included in Journal of Chemical Thermodynamics in 2022.Quality Control of Bisdemethoxycurcumin The following contents are mentioned in the article:
Bisdemethoxycurcumin (BDMC), one of the main curcuminoids, has numerous biol. activities. However, the low solubility and stability of BDMC limit its application. In this work, in order to improve the solubility and stability of BDMC, we encapsulated BDMC using cetyltrimethylammonium bromide (CTAB) + Tween 20/Tween 60 mixed surfactants. The molar ratio of CTAB to Tween 20/Tween 60 was optimized by response surface anal. The thermodn. parameters (binding constant, enthalpy change, entropy change and Gibbs free energy change) for the interaction of BDMC with CTAB + Tween 20/Tween 60 mixed micelles were obtained by fluorescence spectroscopy and UV-visible absorption spectroscopy. Pos. enthalpy change and entropy change indicated that hydrophobic interaction was the main driving force. Moreover, due to the longer alkyl chains of Tween 60, the encapsulation of BDMC by CTAB + Tween 60 mixed micelles was stronger. The encapsulation of BDMC in the hydrophobic alkyl chains by the mixed micelles was determined by fluorescence polarization technol., time-resolved fluorescence assay, and 1H NMR spectroscopy. Solubilization and stability experiments showed that the solubility of BDMC was improved and the alk. hydrolysis of BDMC was inhibited due to the encapsulation of the mixed micelles. The improvement of the solubility and stability of BDMC was more obvious in CTAB + Tween 60 mixed micelles because of the stronger interaction between them. The above results indicated that CTAB + Tween 20/Tween 60 mixed micelles could be used to encapsulate BDMC to improve its solubility and stability. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Quality Control of Bisdemethoxycurcumin).
Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Quality Control of Bisdemethoxycurcumin
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem