Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27191-09-9, name is 3-Methoxyaniline hydrochloride, A new synthetic method of this compound is introduced below., SDS of cas: 27191-09-9
General procedure: To a solution of compound 27 (1 mmol) in 20 mL dried CH2Cl2 was added oxalyl chloride (4 mmol). The mixture was stirred at room temperature for 24 h under argon and then concentrated to dryness under reduced pressure. Hexane (3 * 10 mL) was added to the residue, then concentrated under vacuum to dryness. To a dried CH2Cl2 (20 mL) solution of aniline hydrochloride, 4-methoxyaniline hydrochloride, 4-(trifluoromethoxy)aniline hydrochloride, 4-fluoroaniline hydrochloride, 4-chloroaniline hydrochloride, 4-bromoaniline hydrochloride, 3-methoxyaniline hydrochloride, 3-chloroaniline hydrochloride, 2-methoxyaniline hydrochloride, 2-chloroaniline hydrochloride, benzylamine hydrochloride, 4-methoxybenzylamine hydrochloride, N,N-Dimethylethylenediamine, or pyrrolidine (1.5 mmol) was added to the above acid chloride in the presence of triethylamine (3.0 mmol). The reaction mixture was stirred at room temperature for 3 h under argon and then concentrated. The obtained residue was dissolved in 2:1 MeOH/CH2Cl2 (15 mL) and then NaOMe was added until pH = 10. After stirred at r.t. for 12 h, the solution was neutralized with Dowex 50 * 8 (H+) resin until pH = 7, filtered and concentrated under vacuum. Then the residue was purified by silica gel column chromatography (CH2Cl2-MeOH, 6:1) to give compounds 4-18, respectively.
The synthetic route of 27191-09-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liao, Yixian; Chen, Lizhu; Li, Sumei; Cui, Zi-ning; Lei, Zhiwei; Li, Hui; Liu, Shuwen; Song, Gaopeng; Bioorganic and Medicinal Chemistry; vol. 27; 18; (2019); p. 4048 – 4058;,
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