On December 31, 2020, Lopez-Arencibia, Atteneri; Bethencourt-Estrella, Carlos J.; Freijo, Monica B.; Reyes-Batlle, Maria; Sifaoui, Ines; Nicolas-Hernandez, Desiree San; McNaughton-Smith, Grant; Lorenzo-Morales, Jacob; Abad-Grillo, Teresa; Pinero, Jose E. published an article.Product Details of 93-04-9 The title of the article was New phenalenone analogues with improved activity against Leishmania species. And the article contained the following:
The in vitro activity against Leishmania spp. of five novel designed compounds, phenalenone derivatives, is described in this study. Previous works have shown that some phenalenones present leishmanicidal activity, some of which could induce programmed cell death events in L. amazonensis parasites. In this research, we focused on the determination of the programmed cell death evidence by detecting the characteristic features of the apoptosis-like process, such as phosphatidylserine exposure and mitochondrial membrane potential, among others. The results showed that the new derivatives have comparable or better activity and selectivity than the commonly prescribed anti-leishmanial drug. This result was obtained by inducing stronger mitochondrial depolarization or more intense phosphatidylserine exposure than miltefosine, highlighting compound 8 with moreover 9-times better selectivity index. In addition, the new five mols. activated the apoptosis-like process in the parasite. All the signals observed were indicative of the death process that the parasites were undergoing. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Product Details of 93-04-9
The Article related to leishmania species phenalenone analog phosphatidylserine mitochondrial membrane, leishmania amazonensis, phenalenones, apoptosis-like, chemotherapy, Pharmacology: Methods and other aspects.Product Details of 93-04-9
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