The origin of a common compound about 19500-02-8

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19500-02-8, name is 3-Methoxy-2-methylaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 19500-02-8

[00194] lambda/-fe^Butyloxycarbonyl-2-methyl-3-methoxyaniline (3); [04-035-12]. A stirred solution of amine 2 (42.58 g, 0.31 mol) and di-te/t-butyl dicarbonate (65.48 g, 0.30 mol) in THF (3(T.sect.-m(L) was ‘heated to maintain reflux for 4 h. After cooling to RT, the reaction mixture was concentrated under reduced pressure and the residue was dissolved in EtOAc (500 mL). The resultant solution was washed with 0.5 M citric acid (2×100 mL), water (100 mL), saturated aqueous NaHCO3 (200 mL), brine (200 mL) and dried over MgSO4. After filtration and removal of the solvent from the filtrate, the residue (red oil, 73.6 g) was dissolved in hexanes (500 mL) and filtered through a pad of Silica Gel (for TLC). The filtrate was evaporated under reduced pressure to provide lambda/-Boc aniline 3 as a yellow solid. Yield: 68.1 g (96percent).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ILYPSA, INC.; WO2007/56275; (2007); A2;,
Ether – Wikipedia,
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