On November 15, 2018, Biediger, Ronald J.; Benish, Michele A.; Hardy, Lindsay Bonner; Boyd, Vincent A.; Market, Robert V.; Thrash, Thomas P.; Young, Brandon M. published a patent.HPLC of Formula: 66855-92-3 The title of the patent was Preparation of propionic acid derivatives as α4-integrin inhibitors. And the patent contained the following:
The title compounds I [R1 and R2 = (independently) H, halo, alkyl, cycloalkyl, or arylalkyl; R3 = hydroxy or oxido paired with a pharmaceutically acceptable cation.; R4 = hydroxy, alkoxy, or oxido paired with a pharmaceutically acceptable cation; R5 = (un)substituted Ph, aryl, heteroaryl or arylalkyl; X = CH2, O, or CF2; R6 = (un)substituted alkyl, Ph, aryl, heteroaryl] or pharmaceutically acceptable salts or stereoisomers thereof, useful for antagonizing the action of an α4-integrin to treat various pathophysiol. conditions, were prepared E.g., a multi-step synthesis of sodium 3-[3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido]-3-(3-phenoxyphenyl)propanoate (II), starting from Me propionylacetate and Me formate, was described. Exemplified compounds I were evaluated for their activities as α4-integrin inhibitors (data given for representative compounds I). Pharmaceutical composition comprising compound I was described. The experimental process involved the reaction of 3-(2-Methoxyphenoxy)benzaldehyde(cas: 66855-92-3).HPLC of Formula: 66855-92-3
The Article related to propionic acid derivative propanoate pyridinylureido preparation alpha4 integrin inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 66855-92-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem