On July 31, 1990, Sugimoto, Hachiro; Tsuchiya, Yutaka; Sugumi, Hiroyuki; Higurashi, Kunizo; Karibe, Norio; Iimura, Yoichi; Sasaki, Atsushi; Kawakami, Yoshiyuki; Nakamura, Takaharu published an article.Recommanded Product: Benzyl(4-bromophenyl)sulfane The title of the article was Novel piperidine derivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives. And the article contained the following:
The title compound I (R = H, 2-Me, 4-NO2, 4-MeO, 4-CHO, 4-Cl, 4-PhCH2SO2; R1 = Bz, CH2Ph, CH2CH:CHPh, CH2CH2Ph, CH2C6H4Me-4, CH2C6H4NO2-2; R2 = H, Me, Et, Ph) were prepared and evaluated for antiacetylcholinesterase activity. Substituting the benzamide group with a bulky moiety in the para position led to a substantial increase in activity. Introduction of an alkyl or Ph group at the benzamide nitrogen atom dramatically enhanced the activity. The basicity of the piperidine nitrogen atom appears to play an important role in the increased activity, since the N-benzoylpiperidine derivative was almost inactive. I (R = 4-PhCH2SO2, R1 = CH2Ph, R2 = Me, R)(II) were the most potent inhibitors of acetylcholinesterase and produced significant increases in acetylcholine content in the cerebral cortex and hippocampus of rats. II was chosen for development as an antidementia agent. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Recommanded Product: Benzyl(4-bromophenyl)sulfane
The Article related to acetylcholinesterase inhibiting msbar benzylethylpiperidine, antidementia agent benzylethylpiperidine, dementia treatment agent benzylethylpiperidine, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: Benzyl(4-bromophenyl)sulfane
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