Adding a certain compound to certain chemical reactions, such as: 645-36-3, name is 2,2-Diethoxyethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 645-36-3, Computed Properties of C6H15NO2
49 g of Compound 3 was suspended in a solvent mixture of CH3OH (1 l) and THF (1 l), and 42.4 ml (1.1 eq) of diethyl aminoacetal and 22.8 ml (1.5 eq) of acetic acid were added at room temperature, and the mixture was warmed to 50 C. so that undissolved Compound 3 was completely dissolved, and then the mixture was stirred at room temperature for 1 hour. 18.4 g (1.1 eq) of NaCNBH4 was added at room temperature and the mixture was stirred for 1 hour, followed by performing layer separation using H2O and EA, dehydrating with MgSO4, filtering and drying under reduced pressure, thus obtaining a crude title compound. This crude title compound was purified using column chromatography, yielding 70 g (87.3%) of the title compound (Compound 4). 1H NMR (300 MHz, DMSO-d6, ppm, delta): 9.37 (bs, 1H), 8.28 (s, 1H), 7.69 (d, J=7.58, 1H), 7.49 (bs, 1H), 7.31 (t, J=8.05, 1H), 4.90 (bs, 1H), 4.63 (bs, 2H), 4.15 (s, 3H), 3.60 (m, 4H), 3.15 (bs, 2H), 1.15 (t, J=6.98, 6H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,2-Diethoxyethanamine, and friends who are interested can also refer to it.
Reference:
Patent; JW PHARMACEUTICAL CORPORATION; Chung, Jae-Uk; Kim, Mi-Jung; Lee, Yong-Sil; Ma, Sang-Ho; Cho, Young-Seok; Lee, Sang-Hak; Na, Young-Jun; Kang, Myoung-Joo; Park, Woul-Seong; US2013/196972; (2013); A1;,
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