Xu, Fan; Smith, Myles W. published an article in 2021, the title of the article was A general approach to 2,2-disubstituted indoxyls: total synthesis of brevianamide A and trigonoliimine C.Related Products of 578-58-5 And the article contains the following content:
The indoxyl unit is a common structural motif in alkaloid natural products and bioactive compounds Herein, a general method that transforms readily available 2-substituted indoles into 2,2-disubstituted indoxyls via nucleophile coupling with a 2-alkoxyindoxyl intermediate and showcase its utility in short total syntheses of the alkaloids brevianamide A (7 steps) and trigonoliimine C (6 steps) is reported. The developed method is operationally simple and demonstrates broad scope in terms of nucleophile identity and indole substitution, tolerating 2-alkyl substituents and free indole N-H groups, elements beyond the scope of most prior approaches. Spirocyclic indoxyl products are also accessible via intramol. nucleophilic trapping. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Related Products of 578-58-5
The Article related to indoxyl preparation, indole nucleophile coupling, brevianamide a trigonoliimine c total synthesis, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 578-58-5
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