On September 15, 2022, Baugh, Simon David Peter; Freeman, Kathryn B.; Pelletier, Jeffrey Claude; Reitz, Allen B.; Scott, Richard W.; Weaver, Damian G.; Whitman, David B. published a patent.Application of 152626-77-2 The title of the patent was Novel heteroaromatic compounds exhibiting antifungal activity and their method of use and preparation. And the patent contained the following:
Pharmaceutical compositions of the invention comprise heteroaromatic compounds of formula I having a disease-modifying action in the treatment of fungal infections and diseases associated with fungal infection. Compounds of formula I wherein A1 is (un)substituted thiazolyl, (un)substituted thiadiazolyl, (un)substituted imidazolyl, (un)substituted pyrazinyl, etc.; A2 is (un)substituted pyrimidinyl, (un)substiuted pyrazinyl, (un)substituted oxadiazolyl, (un)substituted thiadiazolyl, etc.; A3 is (CH2)0-2NHC:NHNH2 and derivatives, (CH2)0-2C:NHNH2 and derivatives, OCH2CH2NHC:NHNH2 and derivatives, etc.; A4 is (CH2)0-3NHC:NHNH2 and derivatives, (CH2)0-3C:NHNH2 and derivatives, OCH2CH2NHC:NHNH2 and derivatives, etc.; R1 is H, C1-4 alkyl and C3-5 branched alkyl; and enantiomers, diastereomers, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, are claimed. Example compound II•2TFA was prepared by a multistep procedure (procedure given). The invention compound were evaluated for their antifungal activity (data given). The experimental process involved the reaction of 4-Bromo-5-methoxy-2-methylaniline(cas: 152626-77-2).Application of 152626-77-2
The Article related to heteroaromatic preparation antifungal, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application of 152626-77-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem