New learning discoveries about 366-99-4

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 366-99-4, name is 3-Fluoro-4-methoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 3-Fluoro-4-methoxyaniline

To a sample of 113 (1.011 g, 3.8 mmol) dissolved in acetone (20 mL) was added a solutionof 3-fluoro-p-anisidine (0.541 g, 3.8 mmol) in acetone (10 mL) followed by additionof NaOH (1.52 mL, 2.5 N, 3.8 mmol) and water (3 mL). The reaction mixture was allowed to stir at reflux for about 3 hours under nitrogen. The reaction mixture was extracted 3 times with dichloromethane ; the combined organic layers were washed with brine solution and dried over potassium carbonate. The sample was concentrated on a rotary evaporator and the resulting oil was dried overnight under vacuum. Column chromatography (silica gel, 70: 30 hexanes : ethyl acetate) yielded light yellow solid compound 114 (0.581 g, 42percent), mp98 C ; TLC (silica gel, 30: 70 ethyl acetate: hexanes), Rf 0.36 ; MS (ESI):m/z 369 (39.1), 368 (22.1), 367 (M+H, 100), 273 (3.2), 271 (10.7). Compound 115 was obtained as a by-product (0.159 g) via column chromatography (silica gel, 70: 30 hexanes : ethyl acetate), mp181 C ; TLC (silica gel, 30: 70 ethyl acetate: hexanes), Rf 0.17 ; MS (ESI): nez 472 (M+H, 100), 261 (1.5).

The synthetic route of 366-99-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; REDDY US THERAPEUTICS, INC.; WO2004/26844; (2004); A1;,
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