Liu, Wei; Liu, Sheng; Xie, Hongqi; Qing, Zhixing; Zeng, Jianguo; Cheng, Pi published an article in 2015, the title of the article was TBHP mediated oxidation of N-2-alkynylphenyl α-amino carbonyl compounds to oxalic amides using visible light photoredox catalysis and their application in the synthesis of 2-aryl indoles.Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:
A visible light promoted and TBHP mediated oxidative reaction of N-((2-arylalkynyl)aryl)glycine esters I [R1 = H, 4-Me, 4-F, 4-Cl; R2 = C6H5, Pr, 2-F-C6H4, etc.] to give (2-arylalkynyl)oxalic amides II was developed. In the presence of CuBr and photocatalyst Ru(bpy)3Cl2, the reaction proceeded smoothly to afford the corresponding oxalic amides under the irradiation of 26 W compact fluorescence bulb at room temperature Furthermore, compounds II were further reacted to give 2-aryl indoles III [R1 = H, 5-F; R3 = H, 4-Me, 2-F, 4-F] without an addnl. deacylation step through a favored 5-endo-dig N-cyclization process using AgNO3 as catalyst. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline
The Article related to aryl indole preparation, arylalkynyl oxalic amide preparation silver nitrate catalyst cyclization, tbhp oxidant arylalkynyl glycine ester ruthenium photocatalyst oxidation and other aspects.Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline
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