Adding a certain compound to certain chemical reactions, such as: 458-50-4, name is 4-Bromo-3-fluoroanisole, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 458-50-4, 458-50-4
l-bromo-2-fluoro-4-methoxybenzene (750 mg, 3.658 mmol), potassium acetate (718 mg, 7.32 mmol), l,l’-bis(diphenylphosphino) ferrocene-palladium dichloride dichloromethane adduct (300 mg, 0.367 mmol), bis(pinacolato)diboron (984 mg, 4.39 mmol) and 1,4-dioxane (10 ml) were sealed and subject to microwave irradiation at 140 ¡ãC for a total of 50 minutes (40 min + 10 min). LCMS of aliquot indicated complete consumption of starting material. The reaction crude was filtered through a pad of Celite (521). The filtrate was worked up with brine, extracted with ethyl acetate, dried over Na2SO4, filtered and evaporated to afford a dark oil as the crude mixture of the title compound. To be used as it was for next step. LCMS (ESI) calc. = 252.13; found = 253.09 (M+l)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-fluoroanisole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK & CO., INC.; WO2007/79186; (2007); A2;,
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