Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane, A new synthetic method of this compound is introduced below., name: 2-Bromo-1,1-dimethoxyethane
Step 1. 4-(2,2-Dimethoxyethoxy)-1,2-difluorobenzene Bromoacetaldehyde dimethyl acetal (3.3ml, 27.9mmol) and potassium carbonate (6.5g, 47.1mmol) were added to a solution of 3,4-difluorophenol (3.0g, 23.4mmol) in DMF (65ml). The mixture was heated to 120C for 4 hours, cooled to room temperature and then quenched with a solution of aqueous ammonium chloride. The product was extracted into ethyl acetate, washed with water and brine, dried over magnesium sulphate, filtered and concentrated in vacuo to yield the title compound (5.1g, 97%); 1H NMR (CDCl3) 3.45 (6H, s), 3.93 (2H, d, J 5.1Hz), 4.67 (1H, t, J 5.1Hz), 6.60 (1H, m), 6.74 (1H, m) and 7.03 (1H, m).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SmithKline Beecham plc; EP1232153; (2004); B1;,
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