On May 10, 2021, Jiang, Zhong-Tao; Huang, Jiangkun; Zeng, Yaxin; Hu, Fangdong; Xia, Ying published an article.Synthetic Route of 321-28-8 The title of the article was Rhodium Catalyzed Regioselective C-H Allylation of Simple Arenes via C-C Bond Activation of Gem-difluorinated Cyclopropanes. And the article contained the following:
Herein, we report a rhodium catalyzed directing-group free regioselective C-H allylation of simple arenes. Readily available gem-difluorinated cyclopropanes can be employed as highly reactive allyl surrogates via a sequence of C-C and C-F bond activation, providing allyl arene derivatives in good yields with high regioselectivity under mild conditions. The robust methodol. enables facile late-stage functionalization of complex bioactive mols. The high efficiency of this reaction is also demonstrated by the high turnover number (TON, up to 1700) of the rhodium catalyst on gram-scale experiments Preliminary success on kinetic resolution of this transformation is achieved, providing a promising access to enantio-enriched gem-difluorinated cyclopropanes. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Synthetic Route of 321-28-8
The Article related to arene cyclopropane geminal difluorinated rhodium regioselective allylation catalyst, fluorinated allylarene preparation, c−c bond activation, c−h allylation, directing-group-free, gem-difluorinated cyclopropane, rhodium catalysis and other aspects.Synthetic Route of 321-28-8
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Ether | (C2H5)2O – PubChem