Reference of 36865-41-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36865-41-5, name is 1-Bromo-3-methoxypropane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
NaH (60% suspension in mineral oil, 0.7 g, 17.6 mmol) was added to a solution of 1H-pyrazole (1.0 g, 14.7 mmol) in THF (50 mL) at 0 C. After stirring at 0 C for 0.5 h, 1-bromo-3-methoxypropane (1.6 mL, 17.6 mmol) was added. The mixture was allowed to warm to room temperature. After stirring at room temperature for 16 h, the reaction was quenched with saturated aqueous NH4C1. The mixture was poured into H20 (50 mL), and the aqueous phase was extracted with Et20. The organic phases were combined, washed withaqueous NaOH (1M), dried over Mg504, filtered, and concentrated under reduced pressure to afford the title compound (1.8 g, 88%).?H NMR (500 MHz, CDC13) oe ppm 2.10 – 2.18 (m, 2H), 3.30 – 3.32 (m, 2H), 3.33 (s, 3H), 4.28 (t, J=6.74 Hz, 2H), 6.27 (s, 1H), 7.42 (s, 1H), 7.55 (s, 1H)
The synthetic route of 1-Bromo-3-methoxypropane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PTC THERAPEUTICS, INC.; GERASYUTO, Aleksey, I.; ARNOLD, Michael, A.; CHEN, Guangming; KARP, Gary, Mitchell; QI, Hongyan; TURPOFF, Anthony, A.; WANG, Jiashi; WOLL, Matthew, G.; BRANSTROM, Arthur, A.; NARASIMHAN, Jana; DUMBLE, Melissa, L.; HEDRICK, Jean; WEETALL, Maria, L.; (374 pag.)WO2016/109706; (2016); A1;,
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