Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 122775-35-3, formula is C8H11BO4, Name is 3,4-Dimethoxyphenylboronic acid. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Electric Literature of 122775-35-3.
Zeng, Yan;Nie, Lifei;Liu, Liu;Niu, Chao;Li, Yi;Bozorov, Khurshed;Zhao, Jiangyu;Shen, Jingshan;Aisa, Haji Akber research published 《 Design, synthesis, in vitro evaluation of a new pyrrolo[1,2-a]thiazolo[5,4-d]pyrimidinone derivatives as cholinesterase inhibitors against Alzheimer’s disease》, the research content is summarized as follows. Synthesis of pyrrolo[1,2-a]thiazolo[5,4-d]pyrimidinone derivatives I (R = Ph, 2-methylphenyl, 4-(trifluoromethyl)phenyl, etc.) were designed as cholinesterase inhibitor agents. The in vitro enzyme assays proved that most of the compounds effectively inhibited cholinesterases in the micromolar range with little cytotoxicity. Compound I (R = 4-(trifluoromethyl)phenyl) exhibited the best inhibitory activity against acetylcholinesterase with an IC50 of 2.69±0.17μ M. Kinetic anal. and mol. modeling testified that the competitive inhibition manner of I (R = 4-(trifluoromethyl)phenyl) was more likely to bind to the active center of acetylcholinesterase. Thus, compound I (R = 4-(trifluoromethyl)phenyl) can be considered as promising lead compounds or candidates for the development of novel drugs against Alzheimer’ disease.
Electric Literature of 122775-35-3, 3,4-Dimethoxyphenylboronic acid is a useful research compound. Its molecular formula is C8H11BO4 and its molecular weight is 181.98 g/mol. The purity is usually 95%.
3,4-Dimethoxyphenylboronic acid contains varying amounts of anhydride.
3,4-Dimethoxyphenylboronic acid is a bacterial mutagen. A useful intermediate for organic synthesis.
3,4-Dimethoxyphenylboronic acid is a boronate ester that has been shown to be an effective coupling partner for the Suzuki reaction. It has also been used in cancer therapy and as a photochemical probe for the study of biological properties. 3,4-Dimethoxyphenylboronic acid has been shown to demethylate DNA and inhibit methionine aminopeptidase activity. It also cross-couples with halides, such as chlorides or iodides, and activates tertiary alcohols. 3,4-Dimethoxyphenylboronic acid is soluble in organic solvents and can be used in supramolecular chemistry., 122775-35-3.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem