Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Computed Properties of 38256-93-8.
Song, Jianing;Zhu, Yuqin;Zu, Weidong;Duan, Chunqi;Xu, Junyu;Jiang, Fei;Wang, Xinren;Li, Shuwen;Liu, Chenhe;Gao, Qianqian;Li, Hongmei;Zhang, Yanmin;Tang, Weifang;Lu, Tao;Chen, Yadong research published 《 The discovery of quinoline derivatives, as NF-κB inducing kinase (NIK) inhibitors with anti-inflammatory effects in vitro, low toxicities against T cell growth》, the research content is summarized as follows. In this study, a series of quinoline derivatives I [R = H, OH, (2-methoxyethyl)(methyl)aminyl, 4-methylpiperazin-1-yl, etc.; R1 = 3-hydroxy-3-methylbut-1-yn-1-yl, 2-(1-hydroxycyclopentyl)ethynyl, 3-hydroxy-3-(1,3-thiazol-2-yl)but-1-en-1-yl, etc.; R2 = H, Me] were obtained through rational design and chem. synthesis. Among them, the representative compounds I [R = (2-methoxyethyl)(methyl)aminyl, R1 = 3-hydroxy-3-(1,3-thiazol-2-yl)but-1-yn-1-yl, R2 = H (II); and R = R2 = H, R1 = 3-hydroxy-3-(1,3-thiazol-2-yl)but-1-yn-1-yl (III)] have excellent inhibitory activities on LPS-induced macrophage (J774) nitric oxide release and anti-Con A-stimulated primary T cell proliferation. This evaluation method has good universality and overcomes the obstacles mentioned above, which are faced by the current inhibitor research to a certain extent. Besides, the compound’s II and III toxicity against the growth of T cells under non-stress conditions was evaluated, for the first time, as an indicator for the investigation to avoid potential safety risks. Pharmacokinetic properties evaluation of the less toxic compound III confirmed its good metabolic behavior (especially oral properties, F% = 21.7%), and subsequent development value.
Computed Properties of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem