Ethers do have nonbonding electron pairs on their oxygen atoms, 73724-45-5, formula is C18H17NO5, Name is Fmoc-Ser-OH. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. HPLC of Formula: 73724-45-5.
Simov, Vladimir;Altman, Michael D.;Bianchi, Elisabetta;DelRizzo, Sonia;DiNunzio, Edward N.;Feng, Guo;Goldenblatt, Peter;Ingenito, Raffaele;Johnson, Scott A.;Mansueto, My Sam;Mayhood, Todd;Mortison, Jonathan D.;Serebrov, Victor;Sondey, Christopher;Sriraman, Venkat;Tucker, Thomas J.;Walji, Abbas;Wan, Hui;Yue, Yingzi;Stoeck, Alexander;DiMauro, Erin F. research published 《 Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer》, the research content is summarized as follows. Pathway activating mutations of the transcription factor NRF2 and its neg. regulator KEAP1 are strongly correlative with poor clin. outcome with pemetrexed/carbo(cis)platin/pembrolizumab (PCP) chemo-immunotherapy in lung cancer. Despite the strong genetic support and therapeutic potential for a NRF2 transcriptional inhibitor, currently there are no known direct inhibitors of the NRF2 protein or its complexes with MAF and/or DNA. Herein we describe the design of a novel and high-confidence homol. model to guide a medicinal chem. effort that resulted in the discovery of a series of peptides that demonstrate high affinity, selective binding to the Antioxidant Response Element (ARE) DNA and thereby displace NRF2-MAFG from its promoter, which is an inhibitory mechanism that to our knowledge has not been previously described. In addition to their activity in electrophoretic mobility shift (EMSA) and TR-FRET-based assays, we show significant dose-dependent ternary complex disruption of NRF2-MAFG binding to DNA by SPR, as well as cellular target engagement by thermal destabilization of HiBiT-tagged NRF2 in the NCI-H1944 NSCLC cell line upon digitonin permeabilization, and SAR studies leading to improved cellular stability. We report the characterization and unique profile of lead peptide (1), [(Ac-DELRAKALHIPFPVEKIINLPVVDFNEMMSKEQFN-EAQLALIRDIRRRGKNKVAAQNSRKRKLENIVELEQDLDHLKDEKEKGGhPraA-GSSG-K(DBCO-Cy5)-CONH2)-(Ac-NGTSLTDEELVTMSVRELNQHLRGLSKEEIVQLKQRRRTLKNRGYAASSRVKRVTQKEELEKQKAELQQEVEKGGDabA-CONH2)] which we believe to be a useful in vitro tool to probe NRF2 biol. in cancer cell lines and models, while also serving as an excellent starting point for addnl. in vivo optimization toward inhibition of NRF2-driven transcription to address a significant unmet medical need in non-small cell lung cancer (NSCLC).
73724-45-5, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., HPLC of Formula: 73724-45-5
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem