Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Recommanded Product: Diethylene Glycol Monoethyl Ether.
Sawale, Sunil Rambhau;Shete, R. V.;Bhagat, Vishwas C.;Deshmukh, Madhuri T. research published 《 Nanostuctured lipid based drug delivery system of lopinavir- optimization and evaluation》, the research content is summarized as follows. By using the high-shear homogenization method Nanostructured lipid carriers (NLCs) loaded with lopinavir (LOP) were prepared The LOPNLCs formulations were freeze-dried using POLOXOMER 188 as a cryoprotectant. A burst release is shown by in vitro release studies in simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8). The optimized freeze-dried formulation (LOP-NLC) had a particle size (PS), zeta potential (ZP) and % entrapment efficiency (%EE) of 159.5 _ 3.75 nm, 0.413 _ 0.017, -46 mV and 97.77 _ 4.46%, resp. A spherical shape was observed in the optimized formulation by transmission and scanning electron microscopes. The absence of chem. interaction between the drug and lipids is observed in Differential scanning Calorimetry study. In vitro study is performed using the bulk-equilibrium reverse dialysis technique, to investigate LOP release from optimized LOP-NLC and pure drug suspension in different media. The optimized formulations stored in amber glass container were found to be phys. and chem. stable for three months at room temperature The bioavailability of LOP following oral administration of LOP-NLC in male Wistar rats was found 4.52-fold higher than the LOP-suspension. So the conclusion is:- for improving the oral bioavailability of lopinavir, the nanostructure lipid carriers are potential carriers.
Recommanded Product: Diethylene Glycol Monoethyl Ether, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem