Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. HPLC of Formula: 111-90-0.
Ramanunny, Arya Kadukkattil;Wadhwa, Sheetu;Gulati, Monica;Gupta, Saurabh;Porwal, Omji;Jha, Niraj Kumar;Gupta, Piyush Kumar;Kumar, Deepak;Prasher, Parteek;Dua, Kamal;Saqr, Ahmed Al;Almawash, Saud;Singh, Sachin Kumar research published 《 Development and validation of RP-HPLC method for 1′-Acetoxychavicol acetate (ACA) and its application in optimizing the yield of ACA during its isolation from Alpinia galanga extract as well as its quantification in nanoemulsion》, the research content is summarized as follows. An isocratic RP-HPLC was developed and validated for isolation of 1′-Acetoxychavicol acetate (ACA) from Alpinia galanga extract (AGE). Nucleodur C18 column was used as the stationary phase and mixture of acetonitrile/0.1% formic acid in water (60/40, volume/volume) were used as mobile phase. The elution was carried out with a flow rate of 1 mL/min. Further, the method was validated as per ICH Q2 [R1] guidelines in terms of linearity, LOD, LOQ, recovery, precision and specificity. The validated method was utilized for two purposes i.e. optimizing the isolation of ACA from AGE and quantifying ACA′s concentration and release from its nanoemulsion. To achieve high yield of ACA, Central composite design (CCD) was used to optimize sieve number and solid to solvent ratio. The retention time of standard and isolated ACA were found at 5.63 min and 5.46 min resp. The results indicated that the validated method was linear, accurate, precise and specific. During optimization, excellent correlation was observed between practical yield (3.89 ± 0.23% weight/weight of dried rhizomes) and predicted yield (3.73% weight/weight of dried rhizomes) of ACA with p value more than 0.05. The percentage of ACA loaded in the nanoemulsion was found to be 99.12 ± 0.39. The in vitro diffusion studies showed 90.12 ± 2.21% release of ACA at the end of 24 h. It was concluded that the validated method has been successfully utilized to isolate the ACA from AGE and quantify the amount of ACA present in nanoemulsion.
HPLC of Formula: 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem