Ethers do have nonbonding electron pairs on their oxygen atoms, 122775-35-3, formula is C8H11BO4, Name is 3,4-Dimethoxyphenylboronic acid. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. COA of Formula: C8H11BO4.
Peng, Xiaopeng;Li, Ling;Chen, Jingxuan;Ren, Yichang;Liu, Jin;Yu, Ziwen;Cao, Hao;Chen, Jianjun research published 《 Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma》, the research content is summarized as follows. A series of 2-phenylthiazole analogs I (R = 3,4,5-trimethoxyphenyl, naphthalen-2-yl, 2-fluorophenyl, etc.; n = 1, 2, 3, 4, 5, 6), II (R1 = anthracen-9-yl, 1H-indol-6-yl, 4-chlorophenyl, etc.; R2 = OH, 2-aminophenyl) were designed and synthesized as potential histone deacetylase 6 (HDAC6) inhibitors based on an HDAC6/tubulin dual inhibitor discovered recently and CAY10603 (a known HDAC6 inhibitor). Among them, compound I [R = 2,3-dimethoxyphenyl, n = 6 (III)] was the most potent HDAC6 inhibitor with an IC50 of 31 nM and excellent HDAC6 selectivity (SI = 338 for HDAC6 over HDAC3). Compound III also displayed high antiproliferative activity against various cancer cell lines including the HDACi-resistant YCC3/7 gastric cancer cells (IC50 = 0.16-2.31μM), better than CAY10603. Further, compound III (50 mg/kg) exhibited significant antitumor efficacy in a melanoma tumor model with a tumor growth inhibition (TGI) of 63% without apparent toxicity. Moreover, compound III efficiently enhanced the in vivo antitumor immune response when combined with a small-mol. PD-L1 inhibitor, as demonstrated by the increased tumor-infiltrating lymphocytes and reduced PD-L1 expression levels. The above results suggest that compound III is a promising HDAC6 inhibitor deserving further investigation.
COA of Formula: C8H11BO4, 3,4-Dimethoxyphenylboronic acid is a useful research compound. Its molecular formula is C8H11BO4 and its molecular weight is 181.98 g/mol. The purity is usually 95%.
3,4-Dimethoxyphenylboronic acid contains varying amounts of anhydride.
3,4-Dimethoxyphenylboronic acid is a bacterial mutagen. A useful intermediate for organic synthesis.
3,4-Dimethoxyphenylboronic acid is a boronate ester that has been shown to be an effective coupling partner for the Suzuki reaction. It has also been used in cancer therapy and as a photochemical probe for the study of biological properties. 3,4-Dimethoxyphenylboronic acid has been shown to demethylate DNA and inhibit methionine aminopeptidase activity. It also cross-couples with halides, such as chlorides or iodides, and activates tertiary alcohols. 3,4-Dimethoxyphenylboronic acid is soluble in organic solvents and can be used in supramolecular chemistry., 122775-35-3.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem