Xie, Jialin; Guo, Zhonglin; Huang, Yuanqiong; Qu, Yi; Song, Hongjian; Song, Haibin; Liu, Yuxiu; Wang, Qingmin published an article in 2019, the title of the article was One-Pot Copper-Catalyzed Cascade Bicyclization Strategy for Synthesis of 2-(1H-Indol-1-yl)-4,5-dihydrothiazoles and 2-(1H-Indol-1-yl)thiazol-5-yl Aryl Ketones with Molecular Oxygen as an Oxygen Source.Reference of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:
An atom-economical method for synthesizing N-heterocyclic indoles from readily available o-alkynylphenyl isothiocyanates and propargylamine derivatives is reported. This method involves a copper-catalyzed cascade bicyclization process consisting of an intramol. 5-exo-dig hydrothiolation reaction and an intramol. hydroamination reaction and, depending on whether or not mol. oxygen is present, selectively affords Z-isomers of 2-(1H-indol-1-yl)-4,5-dihydrothiazoles, e.g., I (X-rays single crystal structure shown), or 2-(1H-indol-1-yl)thiazol-5-yl aryl ketones in satisfactory yields. Mechanistic studies indicate that mol. oxygen acts as the oxygen source for the ketone moiety in the products. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Reference of 2-((4-Methoxyphenyl)ethynyl)aniline
The Article related to alkynylphenyl isothiocyanate propargylamine cascade bicyclization copper, indolyl dihydrothiazole preparation mol crystal structure, aryl ketone indolylthiazolyl preparation mol crystal structure, copper cascade bicyclization catalyst and other aspects.Reference of 2-((4-Methoxyphenyl)ethynyl)aniline
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