The origin of a common compound about 102503-23-1

Related Products of 102503-23-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 102503-23-1 as follows.

Reference Example 60; 1- (2, 4-dimethoxyphenyl) -N- { [4-fluoro-5- (2-fluoropyridin-3-yl) – lH-pyrrol-3-yl]methyl }-N-methylmethanamine; Sodium hydride (60% in oil, 2.23 g) was washed twice with hexane and suspended in tetrahydrofuran (180 mL) . To the suspension was added dropwise a solution of l-(2,4- dimethoxyphenyl) -N-methylmethanamine (9.09 g) in tetrahydrofuran (10 mL) at 0C. After the completion of the dropwise addition, the mixture was stirred at 600C for 18 hr. The reaction mixture was cooled to 0C, a solution of 3- (4, 4- difluoro-3-methylene-3, 4-dihydro-2H-pyrrol-5-yl) -2- fluoropyridine (9.64 g) in tetrahydrofuran (10 mL) was added dropwise, and the mixture was stirred at the same temperature for 1 hr. Ice water and saturated brine were added, and the mixture was extracted with ethyl acetate. The extract was washed successively with saturated aqueous ammonium chloride solution, saturated aqueous sodium hydrogen carbonate solution, water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (eluent: ethyl acetate) to give the title compound as a yellow oil (yield 16.8 g, 97%) . 1H-NMR (CDCl3) delta: 2.24(3H,s), 3.51(2H,s), 3.54(2H,s), 3.79(3H,s), 3.80(3H,s), 6.45(lH,s), 6.42-6.50 (IH,m) , 6.68(lH,dd, J=4.7,3.6Hz) , 7.18-7.29 (2H,m) ,7.98 ( IH, ddd, J=4.5, 1.9, 1.5Hz) , 8.25 (IH, ddd, J=IO .2 , 8.0, 1.9Hz) , 8.67(1HzS) .

According to the analysis of related databases, 102503-23-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/108380; (2008); A2;,
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