On March 29, 2021, He, Yu-Ping; Cao, Jian; Wu, Hua; Wang, Qian; Zhu, Jieping published an article.Safety of 2-((4-Methoxyphenyl)ethynyl)aniline The title of the article was Catalytic Enantioselective Aminopalladation-Heck Cascade. And the article contained the following:
Domino processes initiated by intramol. nucleopalladation of alkynes have been developed into powerful synthetic tools for the synthesis of functionalized heterocycles. However, a catalytic enantioselective version of this class of reactions remains scarce. We report herein that reaction of 2-alkynylanilines with prochiral cyclopentenes in the presence of a catalytic amount of Pd(OAc)2, a chiral bidentate pyrox ligand and O2 as terminal oxidant affords the structurally diverse indole-cyclopentene conjugates, e.g., I, bearing two stereocenters in a highly diastereo- and enantio-selective manner. One of the products is converted to a heavily functionalized tetracyclic indolinone derivative The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Safety of 2-((4-Methoxyphenyl)ethynyl)aniline
The Article related to alkynylaniline cyclopentene diastereoselective enantioselective palladium pyrox aminopalladation heck cascade, indole cyclopentene stereoselective preparation, asymmetric synthesis, domino reactions, homogeneous catalysis, nucleopalladation, oxidative heck reactions and other aspects.Safety of 2-((4-Methoxyphenyl)ethynyl)aniline
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