Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Product Details of C6H14O3.
Lee, Seon-Kwang;Ha, Eun-Sol;Park, Heejun;Jeong, Ji-Su;Ryu, Hyo-Jin;Pyo, Yu-Jin;Choi, Du Hyung;Kim, Min-Soo research published ã?Measurement and correlation of solubility of lifitegrast in four mixtures of (diethylene glycol monoethyl ether, glycerol, PEG 400, and propylene glycol + water) from 288.15 K to 308.15 Kã? the research content is summarized as follows. In this study, the solubility of lifitegrast was measured at various temperatures ranging from 288.15-308.15 K in four green solvents + water mixtures through a solid-liquid equilibrium via the shake-flask method. The exptl. mole fraction solubility of lifitegrast increased with increasing temperature The mole fraction solubility of lifitegrast increased as the mass fraction of green solvents increased at a constant temperature, except in diethylene glycol monoethyl ether (DEGME) + water mixtures The mole fraction solubility of lifitegrast in neat polyethylene glycol 400 (PEG 400), which was approx. 33,600 times higher than in neat water at 298.15 K, was the highest solubility overall binary composition Five models, including the van’t Hoff model, modified Apelblat model, simplified CNIBS/R-K model, Sun model, and Ma model were used to correlate and fit the exptl. solubility data of lifitegrast in four green solvents + water mixtures The thermodn. parameters during the dissolution process of lifitegrast in four green solvents + water mixtures, such as enthalpy (ÎH°), Gibbs free energy (ÎG°), and entropy (ÎS°), were estimated using the modified van’t Hoff equation. The solubility data and correlation models could be useful for developing formulations during drug product development, such as eye drops based on these results.
Product Details of C6H14O3, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem