Introduction of a new synthetic route about 707-07-3

According to the analysis of related databases, 707-07-3, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 707-07-3, name is (Trimethoxymethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., Formula: C10H14O3

Step A: Methyl 3-amino-2-(2,2-dimethoxyethylamino)benzoate (922 mg, 3.6 mmol) from Step C of Example 13 was stirred in glacial acetic acid (2.5 mL) and(trimethoxymethyl)benzene (2.0 g, 10.9 mmol) at 70 0C for 3 h. The reaction mixture was cooled to room temperature, concentrated under reduced pressure, and purified by column chromatography (silica gel, 80:20 hexanes/ethyl acetate) to give methyl l-(2,2- dimethoxyethyl)-2-phenyl-lH-benzo[J]imidazole-7-carboxylate as a brown oil (1.0 g, 83%): 1H NMR (500 MHz, CDCl3) delta 7.99 (d, J = 8.0 Hz, I H), 7.95 (d, J= 8.0 Hz, I H), 7.72-7.70 (m, 2H), 7.53-7.51 (m, 3H), 7.33 (t, J = 8.0 Hz, I H), 4.76 (d, J= 5.0 Hz, 2H), 4.24 (t, J= 5.0 Hz, I H), 3.99 (s, 3H), 3.07 (s, 6H); MS (ESI+) m/z 341 (M+H).

According to the analysis of related databases, 707-07-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ALBANY MOLECULAR RESEARCH, INC.; GUZZO, Peter, R.; MANNING, David, D.; EARLY, William; WO2011/8572; (2011); A2;,
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