Application of 1758-46-9,Some common heterocyclic compound, 1758-46-9, name is 2-Phenoxyethylamine, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
b) 2-Methyl-2-{[1-(2-phenoxy-ethylamino)-naphthalene-2-carbonyl]-amino}-propionic acid3 mg copper(l)iodide, 127 mg potassium phosphate and 105 mg 2-[(1-bromo- naphthalene-2-carbonyl)-amino]-2-methyl-propionic acid methyl ester were placed in a reaction vial, which was evaporated and backfilled with argon three times. A solution of 62 mg 2-phenoxyethylamine and 12 mg N,N-diethylsalicylaminde in 0.5 ml of dry DMF was then added via septum. Under inert conditions the reaction mixture was heated to 1000C for 20 h. It was then diluted with ethyl acetate and water, the pH was adjusted to neutral, the layers were separated and the aqueous layer was extracted with ethyl acetate twice. The combined organic layers were dried over magnesium sulphate and evaporated. After purification by RP-HPLC 12 mg 2-methyl-2-{[1-(2-phenoxy- ethylamino)-naphthalene-2-carbonyl]-amino}-propionic acid were obtained.C23H24N2O4 (392.46), LCMS (ESI): 393.16 (MH+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Phenoxyethylamine, its application will become more common.
Reference:
Patent; SANOFI-AVENTIS; WO2008/409; (2008); A1;,
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