In 2022,Rather, Ishfaq Ahmad; Ali, Rashid published an article in ACS Omega. The title of the article was 《An Efficient and Versatile Deep Eutectic Solvent-Mediated Green Method for the Synthesis of Functionalized Coumarins》.Application of 150-19-6 The author mentioned the following in the article:
Herein, we report a green and efficient synthetic route for the construction of diverse functionalized coumarins in good-to-excellent yields (60-98%) via the Pechmann condensation. The optimized synthetic route involves a biodegradable, reusable, and inexpensive deep eutectic solvent (DES) of choline chloride and L-(+)-tartaric acid in a ratio of 1:2 at 110°C. Interestingly, phloroglucinol and Et acetoacetate, upon reaction, furnished the functionalized coumarin (I) in 98% yield within 10 min. On the other front, the same DES at relatively lower reaction temperature (90°C) was found to provide the bis-coumarins in decent yields (81-97%) within 20-45 min. Moreover, this particular method was found to be quite effective for large-scale coumarin synthesis without noteworthy reduction in the yields of the desired products. Noticeably, in this versatile approach, the DES plays a dual role as solvent as well as catalyst, and it was effectively recycled and reused four times with no significant drop-down in the yield of the product. After reading the article, we found that the author used m-Methoxyphenol(cas: 150-19-6Application of 150-19-6)
m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Application of 150-19-6
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem