COA of Formula: C8H8O2In 2020 ,《Modulating Stereoselectivity through Electrostatic Interactions in a SPINOL-Phosphoric Acid-Catalyzed Synthesis of 2,3-Dihydroquinazolinones》 was published in ACS Catalysis. The article was written by Laconsay, Croix J.; Seguin, Trevor J.; Wheeler, Steven E.. The article contains the following contents:
Chiral phosphoric acids have received considerable attention because of their excellent performance in many asym. catalytic reactions. However, the full breadth of means by which the stereoselectivity of these catalysts can be tuned has not been fully elucidated. Herein, the origin of enantioselectivity in a catalytic asym. synthesis of 2,3-dihydroquinazolinones using SPINOL-derived chiral phosphoric acids (ACS Catal.2013, 3, 2244) is explored using d. functional theory computations. We show that the enantioselectivity of this reaction is determined during the intramol. amine addition step of an organocascade sequence and is modulated by differential noncovalent interactions of the substrate with the aryl groups of the catalyst as well as CH···O and NH···O interactions with the phosphate core of the catalyst. Most notably, we demonstrate that the strength of these latter interactions is modulated by their position within the electrostatic environment created by the catalyst. This provides clear evidence of the ability to precisely control the selectivity of an organocatalyzed reaction through the tuning of electrostatic interactions. In the experiment, the researchers used many compounds, for example, 2-Methoxybenzaldehyde(cas: 135-02-4COA of Formula: C8H8O2)
2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.COA of Formula: C8H8O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem