《Unexpected ortho-Heck Reaction under the Catellani Conditions》 was published in Organic Letters in 2020. These research results belong to Rago, Alexander J.; Dong, Guangbin. HPLC of Formula: 529-28-2 The article mentions the following:
An unexpected ortho-Heck reaction was discovered during the study of palladium/norbornene (Pd/NBE) catalysis. Under the Catellani reaction conditions in the presence of lithium salts and olefins, Heck coupling takes place at the ortho position instead of the commonly observed ipso position; meanwhile, a norbornyl group was introduced at the arene ipso position. Systematic deuterium labeling and crossover experiments suggest an unusual 1,4-palladium migration/intramol. hydrogen transfer pathway. The knowledge gained in this study could provide insights for the future development of Pd/NBE catalysis. In addition to this study using 1-Iodo-2-methoxybenzene, there are many other studies that have used 1-Iodo-2-methoxybenzene(cas: 529-28-2HPLC of Formula: 529-28-2) was used in this study.
1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.HPLC of Formula: 529-28-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem