In 2022,Nguyen, Nguyen H.; Oh, Soo Min; Park, Cheol-Min; Shin, Seunghoon published an article in Chemical Science. The title of the article was 《Ortho-selective C-H arylation of phenols with N-carboxyindoles under Bronsted acid- or Cu(I)-catalysis》.Related Products of 150-19-6 The author mentioned the following in the article:
Control over chemo- and regioselectivity is a critical issue in the heterobiaryl synthesis via C-H oxidative coupling. To address this challenge, a strategy to invert the normal polarity of indoles in the heterobiaryl coupling was developed. With N-carboxyindoles as umpoled indoles, an exclusively ortho-selective coupling with phenols was realized for the synthesis of aryl indoles I [R1 = H, 4-Me, 7-F, etc.; R2 = t-Bu, Ph, 1-naphthyl, etc.; Ar’ = 2-OH-4-MeC6H3, 2-OH-5-MeC6H3, 2-OH-4-MeOC6H3, etc.], employing a Bronsted acid- or Cu(I)-catalyst (as low as 0.01 mol%). A range of phenols and N-carboxyindoles coupled with exceptional efficiency and selectivity at ambient temperature and the substrates bearing redox-active aryl halides (-Br and -I) smoothly coupled in an orthogonal manner. Notably, preliminary examples of atropselective heterobiaryl coupling were demonstrated, based on a chiral disulfonimide or a Cu(I)/chiral bisphosphine catalytic system. The reaction was proposed to occur through SN2′ substitution or a Cu(I)-Cu(III) cycle, with Bronsted acid or Cu(I) catalysts, resp.m-Methoxyphenol(cas: 150-19-6Related Products of 150-19-6) was used in this study.
m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRelated Products of 150-19-6
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem