In 2019,Organic Communications included an article by Celik, Hulya; Kuzu, Muslum. Safety of 2-Methoxybenzaldehyde. The article was titled 《Microwave assisted synthesis of N-(methyl and methoxy)benzylidene-4-fluoroaniline derivatives and their carbonic anhydrase I and II inhibition properties》. The information in the text is summarized as follows:
In this study, few Schiff base derivatives I (R = 2-Me, 4-Me, 3-OMe, etc.) were synthesized from Me or methoxy substituted benzaldehydes and 4-fluoroaniline using a microwave method. Their inhibitory effects were studied on carbonic anhydrase isoenzymes (hCA I and II), purified from human erythrocyte cells by Sepharose-4B-L-tyrosine-sulfanilamide affinity chromatog. Among the synthesized compounds I (R = 3-Me, 4-Me, 2-OMe) showed moderate activity on hCA II in the range of IC50 values. The experimental part of the paper was very detailed, including the reaction process of 2-Methoxybenzaldehyde(cas: 135-02-4Safety of 2-Methoxybenzaldehyde)
2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Safety of 2-Methoxybenzaldehyde
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem