《Direct Access to Highly Enantioenriched α-Branched Acrylonitriles through a One-Pot Sequential Asymmetric Michael Addition/Retro-Dieckmann/Retro-Michael Fragmentation Cascade》 was written by Duchemin, Nicolas; Cattoen, Martin; Gayraud, Oscar; Anselmi, Silvia; Siddiq, Bilal; Buccafusca, Roberto; Daumas, Marc; Ferey, Vincent; Smietana, Michael; Arseniyadis, Stellios. Computed Properties of C9H10O2 And the article was included in Organic Letters in 2020. The article conveys some information:
A highly enantioselective synthesis of α-branched acrylonitriles is reported featuring a one-pot sequential asym. Michael addition/retro-Dieckmann/retro-Michael fragmentation cascade. The method, which relies on a solid, bench-stable, and com. available acrylonitrile surrogate, is practical, scalable, and highly versatile and provides a direct access to a wide range of enantioenriched nitrile-containing building blocks. Most importantly, the method offers a new tool to incorporate an acrylonitrile moiety in an asym. fashion. In addition to this study using 2-(Benzyloxy)acetaldehyde, there are many other studies that have used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Computed Properties of C9H10O2) was used in this study.
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Computed Properties of C9H10O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem