Safety of 1-Iodo-2-methoxybenzeneIn 2020 ,《Temperature-modulated selective C(sp3)-H or C(sp2)-H arylation through palladium catalysis》 was published in Chemical Science. The article was written by Gogula, Thirupathi; Zhang, Jinquan; Lonka, Madhava Reddy; Zhang, Shuaizhong; Zou, Hongbin. The article contains the following contents:
Herein, the first example of temperature-dependent selective C-H functionalization of unactivated C(sp3)-H or C(sp2)-H bonds at remote positions through palladium catalysis using 7-pyridyl-pyrazolo[1,5-a]pyrimidine as a new directing group were demonstrated. At 120°C, C(sp3)-H arylation was triggered by the chelation of a rare [6,5]-fused palladacycle, whereas at 140°C, C(sp2)-H arylation proceeded instead through the formation of a 16-membered tetramer containing four 7-pyridyl-pyrazolo[1,5-a]pyrimidine-palladium chelation units. The subsequent mechanistic study revealed that both C-H activations shared a common 6-membered palladacycle intermediate, which was then directly transformed to either the [6,5]-fused palladacycle for C(sp3)-H activation at 120°C or the tetramer for C(sp2)-H arylation at 140°C with catalytic amounts of Pd(OAc)2 and AcOH. Raising the temperature from 120°C to 140°C can also convert the [6,5]-fused palladacycle to the tetramer with the above-mentioned catalysts, hence completing the C(sp2)-H arylation ultimately. In addition to this study using 1-Iodo-2-methoxybenzene, there are many other studies that have used 1-Iodo-2-methoxybenzene(cas: 529-28-2Safety of 1-Iodo-2-methoxybenzene) was used in this study.
1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Safety of 1-Iodo-2-methoxybenzene
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem