Month: February 2023

Axially- and Meso-Substituted Aza-Crown-Ether-Incorporated B^III Subporphyrins: Control of Electron-Donating Ability by Metal Ion Chelation was written by Kise, Koki;Lee, Yu Jin;Tanaka, Takayuki;Kim, Dongho;Osuka, Atsuhiro. And the article was included in European Journal of Inorganic Chemistry in 2021.Computed Properties of C10H21NO4 This article mentions the following:

A series of subporphyrin-based fluorescent probes bearing 1-aza-15-crown-5 or 1-aza-18-crown-6 moieties at the meso or axial positions were prepared by Pd-catalyzed Buchwald-Hartwig amination reaction of the corresponding bromosubporphyrins. Both types of aza-crown-ether-incorporated subporphyrins were fluorescent in solution and exhibited cation-dependent absorption and fluorescence changes. In fluorescence titration experiments, opposite responses were observed for the two types of subporphyrins. Namely, fluorescence quenching occurred for the meso-substituted subporphyrins while fluorescence enhancement was observed for the axially-substituted subporphyrins. These results demonstrate the advantage of subporphyrins being viable to serve as turn-off-type or turn-on-type fluorescence probes, depending upon substitution pattern. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Computed Properties of C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Computed Properties of C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Transition Metal Free Stannylation of Alkyl Halides: The Rapid Synthesis of Alkyltrimethylstannanes was written by Li, Songyi;Lian, Chang;Yue, Guanglu;Zhang, Jianning;Qiu, Di;Mo, Fanyang. And the article was included in Journal of Organic Chemistry in 2022.Safety of 3-(3,4-Dimethoxyphenyl)propan-1-ol This article mentions the following:

A transition metal free stannylation reaction of alkyl bromides and iodides with hexamethyldistannane was developed. This protocol is operationally convenient and features a rapid reaction and good functional group tolerance. A wide range of functionalized primary and secondary alkyl and benzyl tri-Me stannanes were prepared in moderate to excellent yields. The success of the gram-scale procedure and tandem Stille coupling reaction has allowed this protocol to demonstrate potential for application in organic synthesis. Both exptl. and theor. studies reveal the mechanistic details of this stannylation reaction. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Safety of 3-(3,4-Dimethoxyphenyl)propan-1-ol).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Safety of 3-(3,4-Dimethoxyphenyl)propan-1-ol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rapid Crosslinking of Epoxy Thermosets Induced by Solvate Ionic Liquids was written by Hameed, Nishar;Eyckens, Daniel J.;Long, Benjamin M.;Salim, Nisa V.;Capricho, Jaworski C.;Servinis, Linden;De Souza, Mandy;Perus, Magenta D.;Varley, Russell J.;Henderson, Luke C.. And the article was included in ACS Applied Polymer Materials in 2020.Quality Control of 2,5,8,11-Tetraoxadodecane This article mentions the following:

The high-volume manufacture of fiber-reinforced composites faces a huge challenge because long resin curing times put a low ceiling on the total output of parts produced per yr. To translate the benefits from using epoxy in large-volume production platforms, cure cycle times of less than 1 min must be achieved. In this work, we report solvate ionic liquids (SILs) as simple and efficient rapid curing catalytic additives in epoxy systems. Ultrafast curing was observed at low levels of 1-5% of SIL in epoxy resin, and the cure rate is enhanced up to 26-fold without compromising the mech. and thermal properties. Further investigations revealed that enhancement in the cure rate is dependent on the type of SILs employed, influenced by the metal center, the ligands around the metal, and the identity of the counter anion. The relative Lewis acidity of each of the active complexes was calculated, and the rapid cure effect was attributed to the activation of the epoxide moiety via the Lewis acidic nature of the SIL. Making epoxy thermosets rapidly processable enables enormous benefits, finding applications in a whole variety of transformation methods that exist for traditional glass and metals. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Quality Control of 2,5,8,11-Tetraoxadodecane).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Quality Control of 2,5,8,11-Tetraoxadodecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Selective oxidation of benzylic alcohols using Mo(VI) Schiff base complex supported on magnetic nanoparticles as new recoverable heterogeneous catalyst was written by Bovand, Ali;Kargar, Hadi;Fallah-Mehrjardi, Mehdi. And the article was included in Journal of the Iranian Chemical Society in 2022.Product Details of 105-13-5 This article mentions the following:

In the present study, magnetic nanoparticles were functionalized with a dioxomolybdenum(VI) complex containing the tridentate ONO Schiff base ligand obtained from the condensation reaction of 3-ethoxysalicylaldehyde with 4-aminobenzohydrazide. The supported Mo(VI) complex was then characterized by various physicochem. techniques such as Fourier transform IR, field emission SEM, energy-dispersive X-ray spectroscopy , transmission electron microscopy, thermogravimetric anal. , vibrating-sample magnetometer and X-ray diffraction analyses. Moreover, selective oxidation of the various benzylic alcs. was carried out in the presence of the resultant heterogeneous nanocatalyst using H₂O₂ as a safe oxidizing agent in ethanol as a green solvent under reflux conditions. The nanocatalyst can be recovered magnetically and can be reused several times without a remarkable loss of activity. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Product Details of 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Product Details of 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

I. Discovery of a novel series of CXCR3 antagonists. Multiparametric optimization of N,N-disubstituted benzylamines was written by Bata, Imre;Tomoskozi, Zsuzsanna;Buzder-Lantos, Peter;Vasas, Attila;Szeleczky, Gabor;Batori, Sandor;Barta-Bodor, Veronika;Balazs, Laszlo;Ferenczy, Gyorgy G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Formula: C8H8O3 This article mentions the following:

N,N-Disubstituted benzylamine derivatives have been identified as CXCR3 antagonists. Compounds were optimized to improve affinity and selectivity, to increase metabolic stability in human and mouse liver microsomes, to increase Caco-2 permeability. Optimization was supported by monitoring physico-chem. properties using both exptl. and computational means. Several compounds with double-digit nanomolar CXCR3 affinity, favorable selectivity, microsomal stability, Caco-2 permeability and human hepatocyte clearance have been identified. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8Formula: C8H8O3).

3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Formula: C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and liquid-crystalline properties of novel compounds with 3-fluoro-4-cyanophenoxy group was written by Mei, Zhen-Hua;You, Ting-Ting;Bi, Sai. And the article was included in Asian Journal of Chemistry in 2009.COA of Formula: C9H10O4 This article mentions the following:

Facile and convenient synthesis of four series of novel compounds with 3-fluoro-4-cyanophenoxy group were performed by using 2-fluoro-4-hydroxyphenyl as intermediate. The structures of these compounds were characterized by means of elemental anal., IR, NMR (¹H NMR), and mass spectra (MS). One of these compounds was found to exhibit potential liquid-crystalline properties. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4COA of Formula: C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.COA of Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors was written by Choi, Chi;Li, Jia-He;Vaal, Mark;Thomas, Christine;Limburg, David;Wu, Yong-Qian;Chen, Yi;Soni, Raj;Scott, Chad;Ross, Douglas T.;Guo, Hong;Howorth, Pamela;Valentine, Heather;Liang, Shi;Spicer, Dawn;Fuller, Mike;Steiner, Joseph;Hamilton, Gregory S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.Recommanded Product: 3929-47-3 This article mentions the following:

Using simple, inexpensive equipment, we have used solution-phase parallel synthesis to rapidly prepare hundreds of sulfonamide- and urea-containing FKBP inhibitors, resulting in rapid identification of extremely potent compounds in these series. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Recommanded Product: 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Recommanded Product: 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] was written by Amin, Abid M.;Intisar, Azeem;Hussain, Habib;Ali, Zulfiqar;Naz, Asma;Hussain, Shabbir;Shahzady, Tanzeela G.;Waqas, Muhammad. And the article was included in Arabian Journal for Science and Engineering in 2020.Safety of 2-(2-Methoxyethoxy)ethanol This article mentions the following:

The use of polymer-based polyphosphazene is increasing in biomedical industry due to their degradable nature, and their specific role can further be tailored by substituting the chloro groups in the linear precursor with suitable nucleophiles. In this study, we aimed to synthesize a novel degradable polymer based on polyphosphazene by derivatizing the linear poly(dichlorophosphazene) precursor with di-Et amine and 2-(2-methoxyethoxy)ethanol. The structure of the synthesized polymer, poly[bis(2(2-methoxyethoxyethoxy diethylamino))phosphazene] (PMEEDEAP) was elucidated with ¹H NMR and ³¹P NMR. The molar mass distribution and mol. weight of the synthesized polymers were assessed by employing GPC. The hydrolytic degradation, in vitro, of the polymer was carried out in phosphate-buffered saline (PBS) with pH âˆ?7.0 and at 37°C. The polymer showed a weight loss of 95% in 5 wk. Current studies showed that the synthesized degradable polymer may further be subjected to in vivo studies and employed as a potential candidate for biomedical applications, i.e., controlled-drug delivery and tissue engineering. In addition, the exptl. data were analyzed by graphical and statistical methods, and it was found that the weight loss of PMEEDEAP is linear function of time, i.e., w_t = – 1 x 10^-3t_hr + 1.068. The value of the coefficient of determination (R²) is found to be 0.978, which indicates that the workability of the model is good. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Safety of 2-(2-Methoxyethoxy)ethanol).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Safety of 2-(2-Methoxyethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Palladium-Catalyzed Semihydrogenation of Alkynes with EtOH: Highly Stereoselective Synthesis of E – and Z -Alkenes was written by Wang, Chengniu;Dong, Jin;Li, Tingting;Zhao, Xi;Xu, Dawei. And the article was included in Synthesis in 2022.Computed Properties of C18H18O This article mentions the following:

A palladium-catalyzed semihydrogenation of alkynes to E- and Z-alkenes R¹CH=CHR² [R¹ = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.; R² = Ph, 2-ClC₆H₄, 3-pyridyl, etc.; stereo = E, Z] employing EtOH as the hydrogenating agent was reported. The selectivity of the reaction system was effectively controlled by ligand/additive and solvent regulation. The use of sodium acetate/triethanolamine, THF and (1R,2R)-bis[(2-methoxyphenyl)phenylphosphino]ethane [( R,R)-DIPAMP] in CH₃CN was critical for the stereoselective semihydrogenation of alkynes. The general applicability of this procedure was highlighted by the synthesis of more than alkenes, in good yields with high stereoselectivities. In the experiment, the researchers used many compounds, for example, 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1Computed Properties of C18H18O).

1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Computed Properties of C18H18O

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A Simple Halogen-Free Magnesium Electrolyte for Reversible Magnesium Deposition through Cosolvent Assistance was written by Fan, Shengqi;Asselin, Genevieve M.;Pan, Baofei;Wang, Hao;Ren, Yang;Vaughey, John T.;Sa, Niya. And the article was included in ACS Applied Materials & Interfaces in 2020.Related Products of 112-49-2 This article mentions the following:

Rechargeable Mg batteries are one of the most investigated polyvalent-metal storage batteries owing to the increased safety associated with the nondendritic nature of Mg electrodeposition, high volumetric capacity, and low cost. To realize the com. applications of Mg batteries, there are still a number of challenges remaining unsolved, in particular, the lack of halogen-free Mg electrolytes, as the use of the halogens remains a major limiting factor to achieving high voltage cathodes. Work presented here introduces an innovative approach to prepare a halogen-free Mg-based electrolyte in a simple, nonsynthetic method that can plate and strip Mg reversibly. Results suggest that by introducing a secondary amine cosolvent the magnesium bis(trifluoromethanesulfonyl)imide (Mg(TFSI)₂) salt can be easily dissolved into a wide array of polar but aprotic ether solvents. A systematic structural investigation of a representative Mg(TFSI)₂ electrolyte in the cosolvent systems with the secondary amine was performed using pair distribution function (PDF) anal., single crystal diffraction anal., and NMR. The exptl. at. scale understanding reveals an ion pair structure of Mg²⁺ coordinated with six oxygen donors from the bis(trifluoromethanesulfonyl)imide (TFSI) anions and the THF solvent located in the first solvation shell. The as-formed neutral ion pair structure acts as the active component for reversible Mg deposition. We believe this new route of preparing Mg electrolytes can extend the current understanding of Mg electrolyte functionality for rechargeable Mg batteries and offers more guidance for the future electrolyte design. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Related Products of 112-49-2).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Related Products of 112-49-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem