Synthesis and immunosuppressive effects of novel phthalazinone derivatives was written by Wang, Ya-li;Wang, Qing-he;Yang, Hong-guang;Hao, Bo-jun;Liang, Guo-dong;Jiang, Chong-guo;Cheng, Mao-sheng. And the article was included in Yaoxue Xuebao in 2013.Quality Control of 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:
A series of phthalazinone compounds were synthesized and the structures were confirmed by 1H NMR and HR-MS spectrum. All target compounds were obtained through 7 steps, including selective reduction, nitration, bromination, ring enlargement, reduction, Knoevenagel condensation and acylation. The compounds were evaluated for their immunosuppressive effects on T-cell proliferation and inhibitory activity on IMPDH type II in vitro, as well as their structure-activity relationship were assessed. Several compounds exhibited strong immunosuppressive properties, especially compounds 7f and 7h, with IC50 values of 0.093娓璵ol璺疞-1 and 0.14 娓璵ol璺疞-1, resp., which were superior to mycophenolic acid. The information obtained from the studies may be useful for further research on the immunosuppressive agents. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Quality Control of 3-(2,4-Dimethoxyphenyl)acrylic acid).
3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Quality Control of 3-(2,4-Dimethoxyphenyl)acrylic acid
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem