Metabolism of alkenebenzene derivatives in the rat. II. Eugenol and isoeugenol methyl ethers was written by Solheim, Einar;Scheline, Ronald R.. And the article was included in Xenobiotica in 1976.Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol This article mentions the following:
In the rat eugenol Me ether (I) [93-15-2] underwent oxidation of the allylic side chain to form 3 metabolites, 2 of which were excreted as glycine conjugates. Other metabolic reactions were hydroxylation of the benzene ring, O-demethylation, and 2 oxidation reactions; 63-95% of the initial dose was accounted for. The major metabolic path of isoeugenol Me ether (II) [93-16-3] was via cinnamoyl derivatives, but O-demethylation, and oxidation also occurred. Most of the metabolites of I and II were also found in the bile. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol).
3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem