Regio-Selective C3- and N-Alkylation of Indolines in Water under Air Using Alcohols was written by Maji, Milan;Borthakur, Ishani;Srivastava, Sameer;Kundu, Sabuj. And the article was included in Journal of Organic Chemistry in 2022.COA of Formula: C8H10O2 This article mentions the following:
Authors disclosed a regio-selective C-H and N-H bond functionalization of indolines using alcs. in water via tandem dehydrogenation of N-heterocycles and alcs. A diverse range of N- and C3-alkylated indolines/indoles were accessed utilizing a new cooperative iridium catalyst. The practical applicability of this methodol. was demonstrated by the preparative-scale synthesis and synthesis of a psychoactive drug, N,N-dimethyltryptamine. A catalytic cycle is proposed based on several kinetic experiments and a series of control experiments and d. functional theory calculations In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5COA of Formula: C8H10O2).
(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.COA of Formula: C8H10O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem