Synthesis and crystal structure of 2′,4”-O-bis(trimethylsilyl)erythromycin a 9-O-(1-isopropoxycyclohexyl) oxime was written by Liang, Jian-Hua;Yao, Guo-Wei. And the article was included in Heterocycles in 2003.Safety of 1,1-Diisopropoxycyclohexane This article mentions the following:
The ratio of E/Z of 2′-,4”-O-bis(trimethylsilyl)erythromycin A 9-O-(1-isopropoxycyclohexyl) oxime were much higher prepared in CH3CN than those in CH2Cl2. And the ratio would increase with elevation of temperature Compared with 2′-OH, 4”-OH was liable to be silylated in the presence of 1,1,1,3,3,3-hexamethyldisilizane and an NH4+. The crystal structure of E-title compound was determined by single-crystal X-Ray structure anal. to elucidate the origin of regioselectivity occurring at 6-hydroxyl group in the O-methylation of erythromycin A. In the experiment, the researchers used many compounds, for example, 1,1-Diisopropoxycyclohexane (cas: 1132-95-2Safety of 1,1-Diisopropoxycyclohexane).
1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Safety of 1,1-Diisopropoxycyclohexane
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem